Jean-Jacques LATAILLADE

, Hôpital Militaire de Percy, France

Professor Jean Jacques Lataillade is the leader of the Stem Cell Research Laboratory and Skin Cell Therapy Unit of Centre de Transfusion Sanguine des Armées.  He is also a professor of Biology in haematology, transplantation and transfusion.  In 2005, his team performed an innovative culture process for clinical-grade Mesenchymal Stem Cell (MSC) production in which human growth factor-enriched Platelet Lysate replaced animal serum. Regenerative medicine becomes now their main topic especially in the fields of skin repair and wound healing.  They have recently successfully proposed a new approach to radiation burn treatment by combining mesenchymal stem cell therapy with surgery.  They also developed autologous epidermal cultures from keratinocyte progenitors in combination with MSC therapy for large thermal burns.  They have a good technical expertise in MSC isolation and culture from various sources such as Bone Marrow, Adipose Tissue, Wharton Jelly and Placental Membranes and Gingival Mucosa.  Prof. Lataillade is the President of the “Société Française de Bio-ingénierie  Cellulaire et Tissulaire” (S.F.B.C.T.) and the President of the Comité National Professionnel des Vigilances Thérapeutiques Transfusionnelles, Tissulaires et Cellulaires (V3TC). Prof. Lataillade is also a board member of European Tissue Repair Society (ETRS).

 

Top publications:

 

  1. Torossian F, Guerton B, Anginot A, Alexander KA, Desterke C, Soave S, Tseng HW, Arouche N, Boutin L, Kulina I, Salga M, Jose B, Pettit AR, Clay D, Rochet N, Vlachos E, Genet G, Debaud C, Denormandie P, Genet F, Sims NA, Banzet S, Levesque JP, Lataillade JJ, Le Bousse-Kerdilès MC. Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight. 2017 Nov 2;2(21).
  2. Le Burel S, Thepenier C, Boutin L, Lataillade JJ, Peltzer J. Effect of Mesenchymal Stromal Cells on T Cells in a Septic Context: Immunosuppression or Immunostimulation? Stem Cells Dev. 2017 Oct 15;26(20):1477-1489.
  3. Lataillade JJ, Magne B, Bey E, Leclerc T, Trouillas M. Skin engineering for severe burns. Transfus Clin Biol. 2017 Sep;24(3):245-250.
  4. Girard D, Laverdet B, Buhé V, Trouillas M, Ghazi K, Alexaline MM, Egles C, Misery L, Coulomb B, Lataillade JJ, Berthod F, Desmoulière A. Biotechnological Management of Skin Burn Injuries: Challenges and Perspectives in Wound Healing and Sensory Recovery. Tissue Eng Part B Rev. 2017 Feb;23(1):59-82.
  5. Alexaline MM, Trouillas M, Nivet M, Bourreau E, Leclerc T, Duhamel P, Martin MT, Doucet C, Fortunel NO, Lataillade JJ. Bioengineering a human plasma-based epidermal substitute with efficient grafting capacity and high content in clonogenic cells. Stem Cells Transl Med. 2015 Jun;4(6):643-54.
  6. Linard C, Tissedre F, Busson E, Holler V, Leclerc T, Strup C, Couty L, l’Homme B, Benderitter M, Lafont A, Lataillade JJ, Coulomb B. Therapeutic potential of gingival fibroblasts for cutaneous radiation syndrome: Comparison to bone marrow-MSC grafts. Stem Cells Dev. 2015 Jan 13
  7. Peltzer J, Montespan F, Thepenier C, Boutin L, Uzan G, Rouas-Freiss N, Lataillade JJ. Heterogeneous Functions of Perinatal Mesenchymal Stromal Cells Require a Preselection Before Their Banking for Clinical Use. Stem Cells Dev. 2015 Oct 21.

 

Talks