Thomas S.KUPPER, MD

, Department of Dermatology, Brigham and Women's Hospital Harvard Medical School, Boston, USA

Dr. Kupper is the Chair of the Departments of Dermatology at Brigham and Women’s Hospital and the Dana Farber Cancer Institute, and the Thomas B Fitzpatrick Professor of Dermatology at Harvard Medical School.  He is the Director of the Cutaneous Oncology Treatment Center and leads the Cutaneous Lymphoma Program at the Dana Farber Brigham and Women’s Cancer Center.  Dr. Kupper’s research is focused on three general areas: the biology of Cutaneous T Cell Lymphoma, Vaccine Biology and the generation of T cell subsets resident to tissue (TRM), and Cancer Immunobiology.  His current work is supported by the National Institutes for Allergy and Infectious Diseases, the National Institute for Arthritis, Musculoskeletal and Skin Diseases, and the National Cancer Institute. He has received a MERIT award from the NIAID, the first Specialized Program in Research Excellence (SPORE) in Skin Cancer (NCI), and a Transformative Research Award from the NIH Office of the Director.  He has received numerous awards, including the SID William Montagna Award and the SID Kligman-Frost Leadership Award, the JSID Tanioku Kihei Award, the ESDR Rene Touraine Award, the AAD Marion Sulzberger Award,  and is an honorary member of the Korean, Japanese, and Austrian Societies for Investigative Dermatology.   He has been elected to the American Society for Clinical Investigation and American Association of Physicians.

 

Top publications

  1. Liu L, Zhong Q, Tian T, Dubin K, Athale SK, Kupper TS. Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell–mediated immunity.  Nature Medicine. 2010 Feb;16(2):224-7. Epub 2010 Jan 17. PMC3070948.
  2. Jiang X, Clark RA, Liu L, Wagers A, Fuhlbrigge RC, Kupper, TS. Skin infection generates non-migratory memory CD8+ T cells providing global skin immunity.  Nature.  2012 Feb 29;483 (7388):227-31.
  3. Park, Changook, Kupper, TS. The emerging role of resident memory T cells in protective immunity and inflammatory disease.  Nature Medicine 2015 21:688-07.
  4. Gaide O, Emerson RO, Jiang X, Gulati N, Nizza S, Desmarais C, Robins R, Krueger JG, Clark RA, Kupper Common clonal origin of central and resident T cells following skin immunization. Nature Medicine 2015 May 11; 21:647-52. PMC4632197.
  5. Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O’Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA,Kupper TS. Survival of tissue resident memory T cells requires exogneous lipid uptake and metabolism. Nature 2017 Mar 9; 543(7644):252-256 PMC5509051

 

 

Talks